C
Candido Gude
Researcher at Merck & Co.
Publications - 40
Citations - 920
Candido Gude is an academic researcher from Merck & Co.. The author has contributed to research in topics: Thromboxane-A synthase & Thromboxane receptor. The author has an hindex of 16, co-authored 40 publications receiving 858 citations. Previous affiliations of Candido Gude include Novartis & Ciba Specialty Chemicals.
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Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
TL;DR: CGS 16949 A's ability to selectively inhibit aromatase (IC50 = 4.5 nM) over other cytochrome P-450 enzymes and suppress estrogen production when administered orally make it a suitable candidate to test the potential of an aromat enzyme inhibitor in estrogen-dependent diseases including breast cancer.
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Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.
Timothy A. Blizzard,Helen Chen,Seongkon Kim,Jane Y. Wu,Rena Bodner,Candido Gude,Jason E. Imbriglio,Katherine Young,Young-Whan Park,Aimie Ogawa,Susan L. Raghoobar,Nichelle Hairston,Ronald E. Painter,Douglas Wisniewski,Giovanna Scapin,Paula M.D. Fitzgerald,Nandini Sharma,Jun Lu,Sookhee Ha,Jeff Hermes,Milton L. Hammond +20 more
TL;DR: The piperidine analog 3 (MK-7655) effectively restored imipenem's activity against imipanem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations.
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Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.
Neville F. Ford,L. J. Browne,Thomas R. Campbell,C. W. Gemenden,Robert Goldstein,Candido Gude,Jan W. F. Wasley +6 more
TL;DR: The synthesis and structure-activity profile of a new class of potent and highly specific thromboxane A2 synthetase inhibitors is described and the most potent member of this series in vitro is determined to be imidazo[1,5-a]-pyridine-5-hexanoic acid.
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Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.
Norbert Gruenfeld,James L. Stanton,Andrew M. Yuan,Frank H. Ebetino,Leslie J. Browne,Candido Gude,Charles F. Huebner +6 more
TL;DR: The preparation of a series of 1-glutarylindoline-2(S)-carboxylic acid derivatives, 6a-v and 21a-c, is described and the structure-activity relationship of the series is discussed.
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Synthesis of 4-substituted phenylalanines by cross-coupling reactions : extension of the methodology to aryl chlorides
TL;DR: The Suzuki-Miyaura coupling reactions with aromatic chlorides in the presence of catalytic amounts of PdCl2 (PCy3)2 or NiCl2(dppf) were used to produce 4-substituted phenylalanine derivatives as discussed by the authors.