C
Carina Walpole
Researcher at Queensland University of Technology
Publications - 37
Citations - 978
Carina Walpole is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Ghrelin & Cancer. The author has an hindex of 16, co-authored 34 publications receiving 856 citations. Previous affiliations of Carina Walpole include QIMR Berghofer Medical Research Institute & University of Queensland.
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Journal ArticleDOI
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4
Joakim E. Swedberg,Laura V. Nigon,Janet C. Reid,Simon J. de Veer,Carina Walpole,Carson R. Stephens,Terry Walsh,Thomas K. Takayama,John D. Hooper,Judith A. Clements,Ashley M. Buckle,Jonathan M. Harris +11 more
TL;DR: In this article, the Sunflower trypsin inhibitor was designed using a combination of molecular modeling and sparse matrix substrate screening to selectively block the proteolytic activity of KLK4 and prevent stimulation of PAR activity in a cell-based system.
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4
Joakim E. Swedberg,Laura V. Nigon,Janet C. Reid,Simon J. de Veer,Carina Walpole,Carson R. Stephens,Terry Walsh,Thomas K. Takayama,John D. Hooper,Judith A. Clements,Ashley M. Buckle,Jonathan M. Harris +11 more
TL;DR: The naturally occurring sunflower trypsin inhibitor is re-engineer to selectively block the proteolytic activity of KLK4 and prevent stimulation of PAR activity in a cell-based system.
Journal ArticleDOI
Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the α5β1 Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma
Ying Dong,Olivia L. Tan,Daniela Loessner,Carson Stephens,Carina Walpole,Glen M. Boyle,Peter G. Parsons,Judith A. Clements +7 more
TL;DR: A mechanism for the association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients is suggested by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha(5)beta(1) integrin-dependent cell adhesion.
Journal ArticleDOI
The Ghrelin Axis—Does It Have an Appetite for Cancer Progression?
TL;DR: Plasma ghrelin levels are generally inversely related to body mass index and are unlikely to be useful as a biomarker for cancer, but may be Useful as a marker for cancer cachexia and its analogs show promise as treatments for cancer-related cachexia.
Journal ArticleDOI
Ghrelin and cancer
Lisa K. Chopin,Carina Walpole,Inge Seim,Peter Cunningham,Rachael Z. Murray,Eliza Whiteside,Peter Josh,Peter Josh,Adrian C. Herington +8 more
TL;DR: Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR) and has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular and immune systems as mentioned in this paper.