C
Carl E.G. Bruder
Researcher at AstraZeneca
Publications - 4
Citations - 2529
Carl E.G. Bruder is an academic researcher from AstraZeneca. The author has contributed to research in topics: Gene mapping & Point mutation. The author has an hindex of 4, co-authored 4 publications receiving 2324 citations.
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Journal ArticleDOI
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic,Anna Wredenberg,Maria Falkenberg,Johannes N. Spelbrink,Anja T. Rovio,Carl E.G. Bruder,Mohammad Bohlooly-Y,Sebastian Gidlöf,Anders Oldfors,Rolf Wibom,Jan Törnell,Howard T. Jacobs,Nils-Göran Larsson +12 more
TL;DR: The results provide a causative link between mtDNA mutations and ageing phenotypes in mammals by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase.
Journal ArticleDOI
Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia
Mohammad Bohlooly-Y,Bob Olsson,Carl E.G. Bruder,Daniel Lindén,Klara Sjögren,Mikael Bjursell,Emil Egecioglu,Lennart Svensson,Peter Brodin,John C. Waterton,Olle Isaksson,Frank Sundler,Bo Ahrén,Claes Ohlsson,Jan Oscarsson,Jan Törnell +15 more
TL;DR: GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.
Journal ArticleDOI
Gene expression profiling shows that macrophages derived from mouse embryonic stem cells is an improved in vitro model for studies of vascular disease
TL;DR: In this paper, the authors compared the expression profiles of embryonic stem cell-derived macrophages (ES Mphi) and peritoneal mouse macrophage cell lines (J774.A1 and RAW264.7).
Journal ArticleDOI
Refined mapping of the Welander distal myopathy region on chromosome 2p13 positions the new candidate region telomeric of the DYSF locus
TL;DR: The dysferlin gene, a strong candidate gene responsible for two other distal myopathies in the same region, is located centromeric to PAC3-H52 and can thereby formally be excluded as cause for WDM.