A
Anders Oldfors
Researcher at University of Gothenburg
Publications - 280
Citations - 17638
Anders Oldfors is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Myopathy & Mitochondrial DNA. The author has an hindex of 59, co-authored 262 publications receiving 16326 citations. Previous affiliations of Anders Oldfors include Sahlgrenska University Hospital & Linköping University.
Papers
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Journal ArticleDOI
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic,Anna Wredenberg,Maria Falkenberg,Johannes N. Spelbrink,Anja T. Rovio,Carl E.G. Bruder,Mohammad Bohlooly-Y,Sebastian Gidlöf,Anders Oldfors,Rolf Wibom,Jan Törnell,Howard T. Jacobs,Nils-Göran Larsson +12 more
TL;DR: The results provide a causative link between mtDNA mutations and ageing phenotypes in mammals by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase.
Journal ArticleDOI
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
Nils-Göran Larsson,Jianming Wang,Hans Wilhelmsson,Anders Oldfors,Pierre Rustin,Mark Lewandoski,Gregory S. Barsh,David A. Clayton +7 more
TL;DR: The mouse gene for mitochondrial transcription factor A (Tfam), formerly known as m-mtTFA, is disrupted by gene targetting of loxP-sites followed by cre-mediated excision in vivo and is the first mammalian protein demonstrated to regulate mtDNA copy number in vivo.
Book
Muscle Biopsy: A Practical Approach
TL;DR: The procedure of muscle biopsy and definition of pathological changes seen in muscle biopsies are described, as well as some of the commonly used terms.
Journal ArticleDOI
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.
Petri Luoma,Atle Melberg,Juha O. Rinne,Jyrki Kaukonen,Nina N. Nupponen,Richard M Chalmers,Anders Oldfors,Ilkka Rautakorpi,Leena Peltonen,Kari Majamaa,Hannu Somer,Anu Suomalainen +11 more
TL;DR: Cosegregation of parkinsonism and POLG mutations in seven families suggests that when defective, this gene can underlie mendelian transmission of Parkinsonism.
Journal ArticleDOI
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
José P. Silva,Martin Köhler,Caroline Graff,Anders Oldfors,Mark A. Magnuson,Per Olof Berggren,Nils-Göran Larsson +6 more
TL;DR: This animal model reproduces the β-cell pathology of human mitochondrial diabetes and provides genetic evidence for a critical role of the respiratory chain in insulin secretion.