Carles Saus

TL;DR: The results indicate that the activity of COX is increased in skeletal muscle of patients with COPD and chronic respiratory failure, and they suggest that this is likely regulated at the translational level by increasing the number of mitochondrial ribosomes.

TL;DR: It was shown that alveolar macrophages clear NTHI infections by adhesion, phagocytosis, and phagolysosomal processing of the pathogen, and Mechanistically, the data showed that CSE reduced PI3K signaling activation triggered by NTH I, and treatment of CSE-exposed cells with the glucocorticoid dexamethasone reduced the amount of TNF-α secreted upon NTHi infection.

TL;DR: It is found that NTHi invades the airway epithelium by a distinct mechanism, requiring microtubule assembly, lipid rafts integrity, and activation of phosphatidylinositol 3-kinase (PI3K) signalling, and it is shown that PCho is not responsible for Nthi intracellular location.

TL;DR: The results show that lung epithelial cells play a key role as a host defense mechanism against K. pneumoniae pneumonia, using two different strategies: (i) ingestion and control of the microorganisms and (ii) opsonization of themicroorganisms.

TL;DR: It is shown that Minerval also induced apoptosis in Jurkat T‐lymphoblastic leukaemia and other cancer cells, and the effectiveness of this non‐toxic anticancer drug and its wide spectrum against different types of cancer is explained.