C
Carlos A. Donado
Researcher at Boston Children's Hospital
Publications - 1
Citations - 389
Carlos A. Donado is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Pattern recognition receptor & Innate immune system. The author has an hindex of 1, co-authored 1 publications receiving 267 citations.
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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Ivan Zanoni,Ivan Zanoni,Yunhao Tan,Marco Di Gioia,Achille Broggi,Jianbin Ruan,Jianjin Shi,Carlos A. Donado,Feng Shao,Hao Wu,James R. Springstead,Jonathan C. Kagan +11 more
TL;DR: It is reported that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which is called “hyperactive” and induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxP APC and bacterial lipopolysaccharide (LPS).