J
Jianbin Ruan
Researcher at Boston Children's Hospital
Publications - 40
Citations - 6615
Jianbin Ruan is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Pyroptosis & Inflammasome. The author has an hindex of 21, co-authored 32 publications receiving 4099 citations. Previous affiliations of Jianbin Ruan include Harvard University & University of Connecticut.
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Journal ArticleDOI
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu,Zhibin Zhang,Zhibin Zhang,Jianbin Ruan,Jianbin Ruan,Youdong Pan,Venkat Giri Magupalli,Venkat Giri Magupalli,Hao Wu,Hao Wu,Judy Lieberman,Judy Lieberman +11 more
TL;DR: It is shown that GSDMD-NT oligomerizes in membranes to form pores that are visible by electron microscopy and kills cell-free bacteria in vitro and may have a direct bactericidal effect within the cytosol of host cells, but the importance of direct bacterial killing in controlling in vivo infection remains to be determined.
Journal ArticleDOI
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Alvin Lu,Venkat Giri Magupalli,Venkat Giri Magupalli,Jianbin Ruan,Jianbin Ruan,Qian Yin,Qian Yin,Maninjay K. Atianand,Matthijn R. J. Vos,Gunnar F. Schröder,Katherine A. Fitzgerald,Hao Wu,Hao Wu,Edward H. Egelman +13 more
TL;DR: It is proposed that ASC-dependent inflammasomes in both families share a unified assembly mechanism that involves two successive steps of nucleation-induced polymerization.
Journal ArticleDOI
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Charles L. Evavold,Jianbin Ruan,Yunhao Tan,Shiyu Xia,Hao Wu,Jonathan C. Kagan,Jonathan C. Kagan +6 more
TL;DR: It is reported that the pyroptosis regulator gasdermin D (GSDMD) was necessary for IL‐1 secretion from living macrophages that have been exposed to inflammasome activators, such as bacteria and their products or host‐derived oxidized lipids.
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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Jun Jacob Hu,Jun Jacob Hu,Xing Liu,Xing Liu,Xing Liu,Shiyu Xia,Shiyu Xia,Zhibin Zhang,Zhibin Zhang,Ying Zhang,Ying Zhang,Jiangning Zhao,Jiangning Zhao,Jiangning Zhao,Jianbin Ruan,Jianbin Ruan,Jianbin Ruan,Xuemei Luo,Xiwen Lou,Yang Bai,Junhong Wang,L. Robert Hollingsworth,L. Robert Hollingsworth,Venkat Giri Magupalli,Venkat Giri Magupalli,Li Zhao,Li Zhao,Hongbo R. Luo,Hongbo R. Luo,Justin Kim,Judy Lieberman,Judy Lieberman,Hao Wu,Hao Wu +33 more
TL;DR: Disulfiram, an FDA-approved drug for treating alcoholism, is identified as an inhibitor of pore formation by GSDMD but not other members of the GSDM family, providing new therapeutic indications for repurposing this safe drug to counteract inflammation.
Journal ArticleDOI
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Ivan Zanoni,Ivan Zanoni,Yunhao Tan,Marco Di Gioia,Achille Broggi,Jianbin Ruan,Jianjin Shi,Carlos A. Donado,Feng Shao,Hao Wu,James R. Springstead,Jonathan C. Kagan +11 more
TL;DR: It is reported that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which is called “hyperactive” and induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxP APC and bacterial lipopolysaccharide (LPS).