J
James R. Springstead
Researcher at Western Michigan University
Publications - 20
Citations - 1104
James R. Springstead is an academic researcher from Western Michigan University. The author has contributed to research in topics: Endothelial stem cell & Compressed sensing. The author has an hindex of 11, co-authored 19 publications receiving 829 citations. Previous affiliations of James R. Springstead include University of California, Los Angeles & University of Western Ontario.
Papers
More filters
Journal ArticleDOI
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Ivan Zanoni,Ivan Zanoni,Yunhao Tan,Marco Di Gioia,Achille Broggi,Jianbin Ruan,Jianjin Shi,Carlos A. Donado,Feng Shao,Hao Wu,James R. Springstead,Jonathan C. Kagan +11 more
TL;DR: It is reported that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which is called “hyperactive” and induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxP APC and bacterial lipopolysaccharide (LPS).
Journal ArticleDOI
Role of Phospholipid Oxidation Products in Atherosclerosis
Sangderk Lee,Konstantin G. Birukov,Casey E. Romanoski,James R. Springstead,Aldons J. Lusis,Judith A. Berliner +5 more
TL;DR: This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis.
Journal ArticleDOI
By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
TL;DR: It is found that the bacterial lipopolysaccharide receptor CD14 captured extracellular oxPAPC and delivered these lipids into the cell to promote inflammasome‐dependent DC hyperactivation, and it is reported that CD14 captures distinct lipids within oxP APC to promote dendritic cell and/or macrophage hyperactivation.
Journal ArticleDOI
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation.
Marco Di Gioia,Roberto Spreafico,James R. Springstead,Michael M. Mendelson,Roby Joehanes,Daniel Levy,Ivan Zanoni,Ivan Zanoni +7 more
TL;DR: It is demonstrated that oxPAPC generates a distinctive metabolic and hyperinflammatory profile in macrophages that can drive atherosclerosis in mice, thereby underscoring the importance of DAMP-mediated activities in pathophysiological conditions.
Journal ArticleDOI
A novel approach to oral apoA-I mimetic therapy
Arnab Chattopadhyay,Mohamad Navab,Greg Hough,Feng Gao,David Meriwether,Victor Grijalva,James R. Springstead,Mayakonda N. Palgnachari,Ryan Namiri-Kalantari,Feng Su,Brian J. Van Lenten,Alan C. Wagner,Gattadahalli M. Anantharamaiah,Robin Farias-Eisner,Srinivasa T. Reddy,Alan M. Fogelman +15 more
TL;DR: It is suggested that 6F acts in the small intestine and provides a novel approach to oral apoA-I mimetic therapy and positively correlated with the percent of the aorta with lesions.