Carlos A. Paladini

TL;DR: The role of phasic DA was addressed by attenuating DA neuron burst firing and subsequent DA release, without altering tonic neural activity, and dramatically attenuated learning about cues that predicted rewarding and aversive events while leaving many other DA-dependent behaviors unaffected.

TL;DR: The data demonstrate that dopaminergic neurons in vivo are under tonic GABAergic inhibition mediated by GABAA receptors and suggest that GABAergic afferents to substantia nigra comprise a major pathway by which the firing pattern of dopamine neurons is controlled in vivo.

TL;DR: It is demonstrated that dopaminergic neurons of the substantia nigra pars compacta are inhibited by electrical stimulation of striatum, globus pallidus, and the projection neurons of substantia Nigra pars reticulata in vivo.

TL;DR: This review updates recent progress on the expanding behavioral contexts, associated with phasic electrical activity in DA neurons beyond the classical (canonical) reward prediction error model and highlights recently defined contributions of synaptic inputs for burst and pause generation and the roles of distinct postsynaptic ion channels in midbrain DA neurons.

TL;DR: Recordings in urethane anesthetized rats suggest that globus pallidus exerts significant control over the firing rate and pattern of substantia nigra dopaminergic neurons through a disynaptic pathway involving nigral pars reticulata GABAergic neurons and that at least one important way in which local application of bicuculline induces burst firing of dopamine neurons is by disinhibition of this tonic inhibitory input.