C
Carlos Alfonso
Researcher at Spanish National Research Council
Publications - 102
Citations - 3416
Carlos Alfonso is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: FtsZ & Autolysis (biology). The author has an hindex of 30, co-authored 96 publications receiving 3029 citations. Previous affiliations of Carlos Alfonso include Institut national agronomique Paris Grignon.
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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Serene W. Chen,Srdja Drakulic,Emma Deas,Myriam Ouberai,Francesco A. Aprile,Rocío Arranz,Samuel Ness,Cintia Roodveldt,Tim Guilliams,Erwin J. De-Genst,David Klenerman,Nicholas W. Wood,Tuomas P. J. Knowles,Carlos Alfonso,Germán Rivas,Andrey Y. Abramov,José M. Valpuesta,Christopher M. Dobson,Nunilo Cremades +18 more
TL;DR: The findings reveal the inherent multiplicity of the process of protein misfolding and the key role the β-sheet geometry acquired in the early stages of the self-assembly process plays in dictating the kinetic stability and the pathological nature of individual oligomeric species.
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AFLP Linkage Map of the Oomycete Phytophthora infestans
TL;DR: The first comprehensive genetic linkage map of the heterothallic oomycetous plant pathogen Phytophthora infestans is presented, based on polymorphic DNA markers generated by the DNA fingerprinting technique AFLP.
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Infectious bursal disease virus is an icosahedral polyploid dsRNA virus
Daniel Luque,Germán Rivas,Carlos Alfonso,José L. Carrascosa,José F. Rodríguez,José R. Castón +5 more
TL;DR: The results show an unprecedented replicative strategy for dsRNA viruses and suggest that birnaviruses are living viral entities encompassing numerous functional and structural characteristics of positive and negative ssRNA viruses.
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Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop
Sara Alvira,Jorge Cuéllar,Alina Röhl,Soh Yamamoto,Hideaki Itoh,Carlos Alfonso,Germán Rivas,Johannes Buchner,José M. Valpuesta +8 more
TL;DR: The results show that one Hop molecule binds to one side of the Hsp90 dimer in both extended and compact conformations, through Hop domain rearrangement that take place when Hsp70 or Hsp 70:GR-LBD bind to Hsp 90:Hop.
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Purification of a heat-stable chitin deacetylase from Aspergillus nidulans and its role in cell wall degradation.
TL;DR: An extracellular chitin deacetylase activity has been purified to homogeneity from autolyzed cultures of Aspergillus nidulans, an acidic glycoprotein with a pI of 2.75 and a 28% (wt/wt) carbohydrate content.