Rocío Arranz

TL;DR: Mitochondria, cytoplasmic membranes and cytoskeletal components frequently participate in the formation of viral factories, supplying basic and common needs for key steps in the viral replication cycle.

TL;DR: The findings reveal the inherent multiplicity of the process of protein misfolding and the key role the β-sheet geometry acquired in the early stages of the self-assembly process plays in dictating the kinetic stability and the pathological nature of individual oligomeric species.

TL;DR: These findings provide new arguments to support the hypothesis of a dysfunction of Ft (with eventual degradation to Hm) in AD resulting in an increase of toxic brain ferrous ions that may contribute to the production of free radicals that induce both cellular oxidative stress and aged-related myelin breakdown associated with cognitive decline and AD.

TL;DR: The structures reveal how the viral polymerase, RNA genome, and nucleoprotein interact in the RNP provide insight into mechanisms for influenza genome replication and transcription, and the structure of native RNPs derived from virions is described.

TL;DR: Disease status before ASCT is the most important prognostic factor for final outcome; thus, transplantation should be considered in early stages of the disease.