C
Carlos Chih Hsiung Chen
Researcher at Princeton University
Publications - 2
Citations - 1329
Carlos Chih Hsiung Chen is an academic researcher from Princeton University. The author has contributed to research in topics: Fluorescence correlation spectroscopy & Intrinsically disordered proteins. The author has an hindex of 2, co-authored 2 publications receiving 929 citations.
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Journal ArticleDOI
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
Shana Elbaum-Garfinkle,Younghoon Kim,Krzysztof Jakub Szczepaniak,Carlos Chih Hsiung Chen,Christian R. Eckmann,Sua Myong,Clifford P. Brangwynne +6 more
TL;DR: It is demonstrated that an N-terminal, arginine/glycine rich, intrinsically disordered protein (IDP) domain of LAF-1 is necessary and sufficient for both phase separation and RNA–protein interactions, and insight is provided into the mechanism by which IDP-driven molecular interactions give rise to liquid phase organelles with tunable properties.
Journal ArticleDOI
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles.
Ming-Tzo Wei,Shana Elbaum-Garfinkle,Alex S. Holehouse,Carlos Chih Hsiung Chen,Marina Feric,Craig B. Arnold,Rodney D. Priestley,Rohit V. Pappu,Clifford P. Brangwynne +8 more
TL;DR: It is found that LAF-1 and other in vitro and intracellular droplets are characterized by an effective mesh size of ∼3-8 nm, which determines the size scale at which droplet properties impact molecular diffusion and permeability.