Sua Myong

TL;DR: It is demonstrated that an N-terminal, arginine/glycine rich, intrinsically disordered protein (IDP) domain of LAF-1 is necessary and sufficient for both phase separation and RNA–protein interactions, and insight is provided into the mechanism by which IDP-driven molecular interactions give rise to liquid phase organelles with tunable properties.

TL;DR: Cancer-associated mutations in the promoter of the telomerase gene allow increased activation by transcription factor binding, and GABP thus directly links TERT promoter mutations to aberrant expression in multiple cancers.

TL;DR: The shape of RNA can promote the formation and coexistence of the diverse array of RNA-rich liquid compartments found in a single cell and support a model in which structure-based, RNA-RNA interactions promote assembly of distinct droplets and protein-driven, conformational dynamics of the RNA maintain this identity.

TL;DR: Using single-molecule protein-induced fluorescence enhancement, a robust adenosine 5′-triphosphate–powered dsRNA translocation activity of RIG-I is discovered and may provide a means to specifically sense and counteract replicating viruses.

TL;DR: It is shown that NS3 unwinds DNA in discrete steps of about three base pairs, and, upon encountering a barrier or after unwinding >18 bp, it snaps or slips backward rapidly and repeats unwinding many times in succession, which may help to keep secondary structures resolved during viral genome replication.