C
Carlos E. Vanario-Alonso
Researcher at Stony Brook University
Publications - 15
Citations - 1963
Carlos E. Vanario-Alonso is an academic researcher from Stony Brook University. The author has contributed to research in topics: Gap gene & Segmentation gene. The author has an hindex of 12, co-authored 15 publications receiving 1870 citations. Previous affiliations of Carlos E. Vanario-Alonso include State University of New York System & Federal University of Rio de Janeiro.
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Journal ArticleDOI
Dynamic control of positional information in the early Drosophila embryo
Johannes Jaeger,Svetlana Surkova,Maxim Blagov,Hilde Janssens,David Kosman,Konstantin Kozlov,Manu,Ekaterina Myasnikova,Carlos E. Vanario-Alonso,Carlos E. Vanario-Alonso,Maria Samsonova,David H. Sharp,John Reinitz +12 more
TL;DR: This analysis implies that the threshold-dependent interpretation of maternal morphogen concentration is not sufficient to determine shifting gap domain boundary positions, and suggests that establishing and interpreting positional information are not independent processes in the Drosophila blastoderm.
Journal ArticleDOI
Canalization of Gene Expression in the Drosophila Blastoderm by Gap Gene Cross Regulation
Manu,Svetlana Surkova,Alexander V. Spirov,Vitaly V. Gursky,Hilde Janssens,Ah-Ram Kim,Ovidiu Radulescu,Carlos E. Vanario-Alonso,David H. Sharp,Maria Samsonova,John Reinitz +10 more
TL;DR: It is demonstrated that cross regulation between the gap genes causes their expression to approach dynamical attractors, reducing initial variation and providing a robust output, and more generally it is shown that the complex multigenic phenomenon of canalization can be understood at a quantitative and predictive level by the application of a precise dynamical model.
Journal ArticleDOI
Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster.
Johannes Jaeger,Maxim Blagov,David Kosman,Konstantin Kozlov,Manu,Ekaterina Myasnikova,Svetlana Surkova,Carlos E. Vanario-Alonso,Carlos E. Vanario-Alonso,Maria Samsonova,David H. Sharp,John Reinitz +11 more
TL;DR: A detailed analysis of regulatory interactions involved in gap gene regulation based on gap gene circuits, which are mathematical gene network models used to infer regulatory interactions from quantitative gene expression data, suggests a central role for repressive feedback loops between complementary gap genes.
Journal ArticleDOI
Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors.
Manu,Svetlana Surkova,Alexander V. Spirov,Vitaly V. Gursky,Hilde Janssens,Ah-Ram Kim,Ovidiu Radulescu,Carlos E. Vanario-Alonso,David H. Sharp,Maria Samsonova,John Reinitz +10 more
TL;DR: The analysis of the complex phenomena of canalization and pattern formation in the Drosophila blastoderm can be understood in terms of the qualitative features of the dynamical system and confirms the idea that attractors are important for developmental stability and shows a richer variety of dynamical attractors in developmental systems than has been previously recognized.
Journal ArticleDOI
Characterization of the Drosophila segment determination morphome
Svetlana Surkova,David Kosman,Konstantin Kozlov,Manu,Ekaterina Myasnikova,Anastasia Samsonova,Alexander V. Spirov,Carlos E. Vanario-Alonso,Maria Samsonova,John Reinitz +9 more
TL;DR: This system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level, and is the first quantitatively characterized morphogenetic field.