C
Carol Asher
Researcher at Weizmann Institute of Science
Publications - 35
Citations - 1624
Carol Asher is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Epithelial sodium channel & Amiloride. The author has an hindex of 19, co-authored 35 publications receiving 1575 citations.
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Journal ArticleDOI
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
Johannes Loffing,Marija Zecevic,Eric Féraille,Brigitte Kaissling,Carol Asher,Bernard C. Rossier,Gary L. Firestone,David A. Pearce,François Verrey +8 more
TL;DR: It is shown by real-time RT-PCR and immunofluorescence that an aldosterone injection in adrenalectomized rats induces alpha-ENaC subunit expression along the entire ASDN within 2 h, whereas beta- and gamma- ENaC are constitutively expressed.
Journal ArticleDOI
Aldosterone-induced increase in the abundance of Na+ channel subunits.
TL;DR: The data are consistent with the possibility that induction of channel subunits contributes to the chronic but not the acute response to aldosterone in the colon, and are not likely to play a major role in cortical collecting ducts.
Journal ArticleDOI
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel.
TL;DR: regulation of sgk by aldosterone in native mammalian epithelia and its effect on ENaC are characterized to suggest that the response is mediated, at least in part, by occupancy of the mineralocorticoid receptor.
Journal ArticleDOI
Interactions of β and γENaC with Nedd4 Can Be Facilitated by an ERK-mediated Phosphorylation
TL;DR: It is demonstrated that phosphorylating the carboxyl termini of the β and γ subunits facilitates their interactions with the ubiquitin ligase Nedd4 and inhibits channel activity.
Journal ArticleDOI
Aldosterone increases the apical Na+ permeability of toad bladder by two different mechanisms.
Carol Asher,Haim Garty +1 more
TL;DR: It is suggested that aldosterone elevates the apical Na+ permeability of target epithelia by two different mechanisms: a relatively fast effect (less than or equal to 3 hr), which is insensitive to triiodothyronine or butyrate and is not sustained by the isolated membrane, and a slower or later response blocked by these reagents, which is preserved by theolated membrane.