Bernard C. Rossier

TL;DR: The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel.

TL;DR: It is demonstrated that Liddle's syndrome is caused by mutations in the beta subunit of the epithelial sodium channel and have implications for the regulation of this epithelial ion channel as well as blood pressure homeostasis.

TL;DR: In CF airway epithelia, the absence of this second function of CFTR as a cAMP-dependent regulator likely accounts for abnormal sodium transport.

TL;DR: The gene encoding this rat sodium channel subunit shares significant sequence similarity with mec-4 and deg-1, members of a family of Caenorhabditis elegans genes involved in sensory touch transduction and, when mutated, neuronal degeneration, and it is proposed that the gene products of these three genes are member of a gene family coding for cation channels.

TL;DR: It is shown that ENaC plays a critical role in the adaptation of the newborn lung to air breathing and was abolished in airway epithelia from αENaC(−/−) mice that developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid.