Carol L. Farr

TL;DR: The nucleotide sequence of the regions flanking the A + T region of Drosophila melanogaster mitochondrial DNA has been determined and nucleotide substitution analysis reveals that tRNA and rRNA genes evolve at less than half the rate of protein coding genes.

TL;DR: A467T, R627Q, and Q1236H mutations were found to be a common cause of cerebellar ataxia syndrome in the Belgian population as discussed by the authors.

TL;DR: The high mispair specificity of pol γ in exonucleolytic hydrolysis is maintained, indicating that enhancement ofPol γ catalytic efficiency is likely not accompanied by increased nucleotide turnover, and their functional coordination and a similar mechanism of stimulation by mtSSB are suggested.

TL;DR: It is concluded that the length heterogeneity observed in the A+T regulatory region in mitochondrial DNAs from the genus Drosophila results from the expansion (and contraction) of the number of repeated DNA sequence elements.

TL;DR: In this article, the discovery that several inherited human diseases are caused by mtDNA depletion has led to an increased interest in the replication and maintenance of mtDNA, and a new mutant was identified.