C
Carolea Logun
Researcher at National Institutes of Health
Publications - 61
Citations - 2789
Carolea Logun is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene expression & Phospholipase A2. The author has an hindex of 31, co-authored 61 publications receiving 2645 citations.
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Tumor necrosis factor-alpha induces mucin hypersecretion and muc-2 gene expression by human airway epithelial cells
TL;DR: Increases in MUC-2 steady-state mRNA levels were first detectable after 30 min of TNF-alpha stimulation and persisted for 24 h, suggesting that new protein translation was not required.
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Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease
Maria L. Jison,Peter J. Munson,Jennifer J. Barb,Anthony F. Suffredini,Shefali Talwar,Carolea Logun,Nalini Raghavachari,John H. Beigel,James H. Shelhamer,Robert L. Danner,Mark T. Gladwin +10 more
TL;DR: Global transcriptional analysis of circulating leukocytes highlights the intense oxidant and inflammatory nature of steady-state sickle cell disease and provides insight into the broad compensatory responses to vascular injury.
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Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease
Nalini Raghavachari,Xiuli Xu,Amy Harris,Jose Villagra,Carolea Logun,Jennifer J. Barb,Michael A. Solomon,Anthony F. Suffredini,Robert L. Danner,Gregory J. Kato,Peter J. Munson,Sidney M. Morris,Mark T. Gladwin +12 more
TL;DR: A potential pathogenic role for platelet arginase and altered arginine and polyamine metabolism in sickle cell disease is suggested and a novel framework for the study of disease-specific platelet biology is provided.
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages
Milena Sokolowska,Li-Yuan Chen,Yueqin Liu,Asuncion Martinez-Anton,Hai-Yan Qi,Carolea Logun,Sara Alsaaty,Yong Hwan Park,Daniel L. Kastner,Jae Jin Chae,James H. Shelhamer +10 more
TL;DR: The results suggest that PGE2 might play a role in maintaining homeostasis during the resolution phase of inflammation and might serve as an autocrine and paracrine regulator.
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Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line
TL;DR: The results suggest that corticosteroids have a differential effect on the regulation of cytokine secretion by human bronchial epithelial cells.