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Caroline Granycome
Researcher at Hoffmann-La Roche
Publications - 1
Citations - 228
Caroline Granycome is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Replicon & Hepatitis C virus. The author has an hindex of 1, co-authored 1 publications receiving 224 citations.
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The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture *
Klaus Klumpp,Vincent Leveque,Sophie Le Pogam,Han Ma,Wen-Rong Jiang,Hyunsoon Kang,Caroline Granycome,Margaret Singer,Carl Laxton,Julie Qi Hang,Keshab Sarma,David Bernard Smith,Dieter Heindl,Christopher John Hobbs,John Herbert Merrett,Julian Symons,Nick Cammack,Joseph A. Martin,Rene Devos,Isabel Najera +19 more
TL;DR: Hepatitis C virus (HCV) polymerase activity is essential for HCV replication and the corresponding 5′-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity.