Nick Cammack

TL;DR: Passage of human immunodeficiency virus type 1 in the presence of increasing 2'-deoxy-3'-thiacytidine (3TC) concentrations results in high-level (> 100-fold) 3TC-resistant viruses that demonstrate an enantiomeric specificity for viruses selected under these conditions.

TL;DR: The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2, however, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)- enantiomer.

TL;DR: Fusion inhibitors block the last step in the three-step viral entry process consisting of attachment, co-receptor binding and fusion, thereby preventing viral capsid entry into the host cell.

TL;DR: 3TC is a potent and selective inhibitor of HIV-1 and HIV-2 replication in vitro and has no detectable antiviral activity against a range of other viruses or in cells chronically infected with HIV- 1 or HIV- 2.

TL;DR: Hepatitis C virus (HCV) polymerase activity is essential for HCV replication and the corresponding 5′-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity.