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Carolyn K. Goldman
Researcher at National Institutes of Health
Publications - 87
Citations - 7662
Carolyn K. Goldman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antibody & Receptor. The author has an hindex of 44, co-authored 87 publications receiving 7354 citations. Previous affiliations of Carolyn K. Goldman include Rockefeller University.
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Journal ArticleDOI
Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
Kevin C. Conlon,Enrico Lugli,Hugh C. Welles,Hugh C. Welles,Steven A. Rosenberg,Antonio Tito Fojo,John C. Morris,Thomas A. Fleisher,Sigrid Dubois,Liyanage P. Perera,Donn M. Stewart,Carolyn K. Goldman,Bonita R. Bryant,Jean M. Decker,Jing Chen,Tatyana Worthy,William D. Figg,Cody J. Peer,Michael C. Sneller,H. Clifford Lane,Jason L. Yovandich,Stephen P. Creekmore,Mario Roederer,Thomas A. Waldmann +23 more
TL;DR: IL-15 could be safely administered to patients with metastatic malignancy and markedly altered homeostasis of lymphocyte subsets in blood, with NK cells and γδ cells most dramatically affected, followed by CD8 memory T cells.
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The Sézary syndrome: a malignant proliferation of helper T cells.
Samuel Broder,Richard L. Edelson,Marvin A. Lutzner,David L. Nelson,Richard P. Macdermott,Mary E. Durm,Carolyn K. Goldman,Bruce D. Meade,Thomas A. Waldmann +8 more
TL;DR: The results presented in this paper suggest that neoplastic lymphocytes from the majority of patients with the Sézary syndrome originate from a subset of T cells programmed exclusively for helper-like interactions with B cells in their production of immunoglobulin molecules.
Journal ArticleDOI
Expression of interleukin 2 receptors on activated human B cells.
Thomas A. Waldmann,Carolyn K. Goldman,Richard J. Robb,Joel M. Depper,Warren J. Leonard,Susan O. Sharrow,Kathleen F. Bongiovanni,Stanley J. Korsmeyer,Warner C. Greene +8 more
TL;DR: The data suggest that IL-2 may play a role in the differentiation of activated B cells into immunoglobulin-synthesizing and -secreting cells.
Journal ArticleDOI
Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex
TL;DR: An IL-2 binding peptide is identified that does not react with anti-humanIL-2 receptor monoclonal antibodies, including anti-Tac on MLA 144, a gibbon ape T-cell line.
Journal ArticleDOI
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
Richard N. Bamford,Angus Grant,Jack D. Burton,Christian J. Peters,Gloria Kurys,Carolyn K. Goldman,J Brennan,Erich Roessler,Thomas A. Waldmann +8 more
TL;DR: The IL-T-mediated stimulation of T-cell and lymphokine-activated killer cell activation requires the expression of the IL-2R beta subunit.