C
Carter A. Mitchell
Researcher at National Institutes of Health
Publications - 15
Citations - 2042
Carter A. Mitchell is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Aldosterone & Mineralocorticoid. The author has an hindex of 10, co-authored 15 publications receiving 1914 citations. Previous affiliations of Carter A. Mitchell include Woodward, Inc. & West Virginia University.
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Journal ArticleDOI
Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney
TL;DR: At the protein level, the response of ENaC to aldosterone stimulation is heterogenous, with both quantitative and qualitative changes that can explain observed increases in ENac-mediated sodium transport.
Journal ArticleDOI
The thiazide-sensitive Na–Cl cotransporter is an aldosterone-induced protein
Gheun-Ho Kim,Shyama Masilamani,R. J. Turner,Carter A. Mitchell,James B. Wade,James B. Wade,Mark A. Knepper +6 more
TL;DR: It is concluded that the distal convoluted tubule is an important site of action of the mineralocorticoid aldosterone, which strongly up-regulates the expression of TSC.
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Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle’s loop
Gheun-Ho Kim,Carolyn A. Ecelbarger,Carter A. Mitchell,Randall K. Packer,James B. Wade,James B. Wade,Mark A. Knepper +6 more
TL;DR: It is concluded that vasopressin strongly upregulates the expression of the Na-K-2Cl cotransporter of the TAL and that it is likely to play an important role in the long-term regulation of the countercurrent multiplication system.
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Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney
Carolyn A. Ecelbarger,Gheun-Ho Kim,James Terris,Shyama Masilamani,Carter A. Mitchell,Ivan Reyes,Joseph G. Verbalis,Mark A. Knepper +7 more
TL;DR: All three subunits of ENaC are upregulated by vasopressin with temporal and regional differences, but changes are too slow to play a major role in the short-term action of vasoppressin to stimulate sodium reabsorption in the collecting duct.
Journal ArticleDOI
UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin.
James B. Wade,A. J. Lee,Jie Liu,Carolyn A. Ecelbarger,Carter A. Mitchell,A. D. Bradford,James Terris,Gheun-Ho Kim,Mark A. Knepper +8 more
TL;DR: Results indicate that UT-A2 is expressed as a 55-kDa protein in portions of the thin descending limbs of Henle's loop and that the abundance of this protein is strongly upregulated by vasopressin.