C
Caryn E. Outten
Researcher at University of South Carolina
Publications - 41
Citations - 5385
Caryn E. Outten is an academic researcher from University of South Carolina. The author has contributed to research in topics: Glutaredoxin & Iron–sulfur cluster. The author has an hindex of 28, co-authored 41 publications receiving 4963 citations. Previous affiliations of Caryn E. Outten include Johns Hopkins University & Northwestern University.
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Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
TL;DR: The mechanism of zinc sensors that control metal uptake or export in Escherichia coli are determined and their response against the thermodynamically defined free zinc concentration suggests an extraordinary intracellular zinc-binding capacity.
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Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
Anita Changela,Kui Chen,Yi Xue,Jackie Holschen,Caryn E. Outten,Thomas V. O'Halloran,Alfonso Mondragón +6 more
TL;DR: An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding, which is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
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Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR.
TL;DR: YbbI is designated ybbIas cueR for the Cu effluxregulator and represents the first example of a copper-responsive regulon on the E. coli chromosome and further extends the roles of MerR family members in prokaryotic stress response.
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The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix
TL;DR: Green fluorescent protein-based redox sensor targeted to the intermembrane space (IMS) and matrix of yeast mitochondria indicates that redox control in the cytosol and matrix are maintained separately by cytosolic and mitochondrial isoforms of GSSG reductase.
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Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.
Attila Kumánovics,Opal S. Chen,Liangtao Li,Dustin Bagley,Erika M. Adkins,Huilan Lin,Nin N. Dingra,Caryn E. Outten,Greg Keller,Dennis R. Winge,Diane M. Ward,Jerry Kaplan +11 more
TL;DR: Results show that the Fra-Grx complex is an intermediate between the production of mitochondrial Fe-S clusters and transcription of the iron regulon, and shows that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion.