O
Opal S. Chen
Researcher at University of Utah
Publications - 18
Citations - 1937
Opal S. Chen is an academic researcher from University of Utah. The author has contributed to research in topics: Frataxin & Mitochondrion. The author has an hindex of 12, co-authored 17 publications receiving 1597 citations. Previous affiliations of Opal S. Chen include Huntsman Cancer Institute.
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Journal ArticleDOI
Deficiency of glutaredoxin 5 reveals Fe–S clusters are required for vertebrate haem synthesis
Rebecca A. Wingert,Jenna L. Galloway,Bruce A. Barut,Helen Foott,Paula G. Fraenkel,Jennifer L. Axe,Gerhard J. Weber,Kimberly Dooley,Alan J. Davidson,Bettina Schmidt,Barry H. Paw,Barry H. Paw,George C. Shaw,George C. Shaw,Paul D. Kingsley,James Palis,Heidi L. Schubert,Opal S. Chen,Jerry Kaplan,Leonard I. Zon +19 more
TL;DR: It is shown that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe–S cluster assembly, indicating that haemoglobin production in the differentiating red cell is regulated through Fe– S cluster assembly.
Journal ArticleDOI
CCC1 is a transporter that mediates vacuolar iron storage in yeast.
TL;DR: Results indicate that yeast can store iron in the vacuole and that CCC1 is involved in the transfer of iron from the cytosol to the vacUole.
Journal ArticleDOI
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.
Attila Kumánovics,Opal S. Chen,Liangtao Li,Dustin Bagley,Erika M. Adkins,Huilan Lin,Nin N. Dingra,Caryn E. Outten,Greg Keller,Dennis R. Winge,Diane M. Ward,Jerry Kaplan +11 more
TL;DR: Results show that the Fra-Grx complex is an intermediate between the production of mitochondrial Fe-S clusters and transcription of the iron regulon, and shows that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion.
Journal ArticleDOI
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
Abbie S. Ireland,Alexi M. Micinski,David W. Kastner,Bingqian Guo,Sarah J. Wait,Kyle B. Spainhower,Christopher C. Conley,Opal S. Chen,Matthew R. Guthrie,Danny Soltero,Yi Qiao,Xiaomeng Huang,Szabolcs Tarapcsák,Siddhartha Devarakonda,Milind D. Chalishazar,Jason Gertz,Justin C. Moser,Gabor T. Marth,Sonam Puri,Benjamin L. Witt,Benjamin T. Spike,Trudy G. Oliver +21 more
TL;DR: It is revealed that mouse and human models with a time-series single-cell transcriptome analysis reveal that MYC drives dynamic evolution of SCLC subtypes, suggesting that genetics, cell of origin, and tumor cell plasticity determine SclC subtype.
Journal ArticleDOI
Transcription of the Yeast Iron Regulon Does Not Respond Directly to Iron but Rather to Iron-Sulfur Cluster Biosynthesis
TL;DR: It is demonstrated that transcription of FET3 and FTR1 genes does not respond directly to cytosolic iron but rather to the mitochondrial utilization of iron for the synthesis of iron-sulfur (Fe-S) clusters.