C
Casper Bindzus Foldager
Researcher at Aarhus University Hospital
Publications - 62
Citations - 1791
Casper Bindzus Foldager is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 24, co-authored 61 publications receiving 1484 citations. Previous affiliations of Casper Bindzus Foldager include Aarhus University & VA Boston Healthcare System.
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Journal ArticleDOI
Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration.
TL;DR: The emerging role of MSCs in Cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration are discussed.
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Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes.
Casper Bindzus Foldager,Samir Munir,Michael Ulrik-Vinther,Kjeld Søballe,Cody Bünger,Martin Lind +5 more
TL;DR: RPL13A, B2M and RPII are recommended as the best choice for qRT-PCR analyses when comparing normoxic and hypoxic cultured human chondrocytes although other genes might also be suitable.
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Poor osteochondral repair by a biomimetic collagen scaffold: 1- to 3-year clinical and radiological follow-up
Bjørn Borsøe Christensen,Casper Bindzus Foldager,Jonas Jensen,Niels Christian Jensen,Martin Lind +4 more
TL;DR: Treatment of osteochondral defects in the ankle and knee joint with a biomimetic scaffold resulted in incomplete cartilage repair and poor subchondral bone repair at 1- and 2.5-year timescales post-operatively, and this results raise serious concerns about the biological repair potential of the MaioRegen® scaffold.
Journal ArticleDOI
Cellular senescence in aging and osteoarthritis.
Wei Seong Toh,Mats Brittberg,Jack Farr,Casper Bindzus Foldager,Andreas H. Gomoll,James Hoi Po Hui,James B. Richardson,Sally Roberts,Myron Spector +8 more
TL;DR: This review discusses the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair, and presents novel strategies for modulation of cellularsenescence that may help to improve cartilage regeneration in an aging population.
Journal ArticleDOI
Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes.
Casper Bindzus Foldager,Anna Bay Nielsen,Samir Munir,Michael Ulrich-Vinther,Kjeld Søballe,Cody Bünger,Martin Lind +6 more
TL;DR: The findings suggest that there was a combined positive effect of 3D culture and hypoxia on cartilage-specific gene expression, suggesting that seeding of chondrocytes onto a scaffold for matrix-assisted chondROcyte implantation should be performed earlier than 2 days before implantation.