C
Catalina Lopez de Lara
Researcher at McGill University
Publications - 5
Citations - 236
Catalina Lopez de Lara is an academic researcher from McGill University. The author has contributed to research in topics: Suicide prevention & CREB. The author has an hindex of 4, co-authored 5 publications receiving 225 citations.
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Journal ArticleDOI
Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression.
Catalina Lopez de Lara,Jelena Brezo,Guy A. Rouleau,Alain Lesage,Mimi Dumont,Martin Alda,Chawki Benkelfat,Gustavo Turecki +7 more
TL;DR: The TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in MDD; however, the findings do not support the role of IABs as mediators.
Journal ArticleDOI
STin2 variant and family history of suicide as significant predictors of suicide completion in major depression.
Catalina Lopez de Lara,Alexandre Dumais,Guy A. Rouleau,Alain Lesage,Mimi Dumont,Nadia Chawky,Martin Alda,Chawki Benkelfat,Gustavo Turecki +8 more
TL;DR: The 5-HTT gene-linked polymorphic region (5-HTTLPR) and intron 2 (STin2) variants of this gene and their relationship to behavioral and clinical risk factors for suicide are investigated to identify predictors of suicide.
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Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses
Catalina Lopez de Lara,Iris Jaitovich-Groisman,Cristiana Cruceanu,Firoza Mamdani,Veronique Lebel,Volodymyr Yerko,Angus Beck,L. Trevor Young,Guy A. Rouleau,Paul Grof,Martin Alda,Gustavo Turecki +11 more
TL;DR: Evidence of linkage to lithium-responsive BD on 3p25, 3p14 and 14q11 as well as significantly dysregulated genes on these regions suggesting altered synaptic and mitochondrial function in BD is found.
Journal ArticleDOI
Alterations in phosphorylated cAMP response element-binding protein (pCREB) signaling: an endophenotype of lithium-responsive bipolar disorder?
Martin Alda,Li Shao,Jun-Feng Wang,Catalina Lopez de Lara,Iris Jaitovich-Groisman,Veronique Lebel,Xiujun Sun,Anne Duffy,Paul Grof,Guy A. Rouleau,Gustavo Turecki,L. Trevor Young +11 more
TL;DR: Abnormalities of signal transduction are considered among the susceptibility factors for bipolar disorder (BD) and changes in G‐protein‐mediated signaling and subsequent modification of gene expression via transcription factors such as cAMP response element‐binding protein (CREB).