C
Catherine E. M. Allsopp
Researcher at John Radcliffe Hospital
Publications - 29
Citations - 5811
Catherine E. M. Allsopp is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Human leukocyte antigen & Antigen. The author has an hindex of 21, co-authored 29 publications receiving 5720 citations. Previous affiliations of Catherine E. M. Allsopp include National Institute for Medical Research & Imperial College London.
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Journal ArticleDOI
Common West African HLA antigens are associated with protection from severe malaria
Adrian V. S. Hill,Catherine E. M. Allsopp,Dominic P. Kwiatkowski,Nicholas M. Anstey,Patrick Twumasi,P. Rowe,Stephen Bennett,David Brewster,Andrew J. McMichael,Brian M. Greenwood +9 more
TL;DR: Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Journal ArticleDOI
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
William McGuire,Adrian V. S. Hill,Catherine E. M. Allsopp,Brian Greenwood,Dominic P. Kwiatkowski +4 more
TL;DR: The maintenance of the TNF2 allele at a gene frequency of 0.16 in The Gambia implies that the increased risk of cerebral malaria in homozygotes is counterbalanced by some biological advantage, suggesting that regulatory polymorphisms of cytokine genes can affect the outcome of severe infection.
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Molecular analysis of the association of HLA-B53 and resistance to severe malaria.
Adrian V. S. Hill,John Elvin,Antony C. Willis,M. Aidoo,Catherine E. M. Allsopp,Frances M. Gotch,Xiao-Ming Gao,Masafumi Takiguchi,Brian Greenwood,Alain Townsend +9 more
TL;DR: Findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.
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Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.
C Ruwende,S C Khoo,Robert W. Snow,S N Yates,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Sunetra Gupta,Peter Warn,Peter Warn,Catherine E. M. Allsopp,Sarah C. Gilbert,N Peschu +11 more
TL;DR: In two large case-control studies of over 2,000 African children, the common African form of G6PD deficiency is associated with a 46á¤-58% reduction in risk of severe malaria for both female heterozygotes and male hemizygotes.
Journal ArticleDOI
Association between an MHC Class II Allele and Clearance of Hepatitis B Virus in the Gambia
Mark Thursz,Dominic P. Kwiatkowski,Catherine E. M. Allsopp,Brian Greenwood,Howard C. Thomas,Adrian V. S. Hill +5 more
TL;DR: The MHC class II allele DRB1*1302 was associated with protection against persistent HBV infection among both children and adults in the Gambia and possible associations with HLA class I antigens found in children were not supported by the data on adults.