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Antony C. Willis
Researcher at University of Oxford
Publications - 85
Citations - 9029
Antony C. Willis is an academic researcher from University of Oxford. The author has contributed to research in topics: Peptide sequence & Antigen. The author has an hindex of 49, co-authored 85 publications receiving 8779 citations.
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Journal ArticleDOI
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
TL;DR: A peptide, of calculated molecular mass 3905 Da, that was a major protein component of amyloid-rich pancreatic extracts of three type 2 diabetic patients is described, indicating that these peptides are related in evolution.
Journal ArticleDOI
Molecular analysis of the association of HLA-B53 and resistance to severe malaria.
Adrian V. S. Hill,John Elvin,Antony C. Willis,M. Aidoo,Catherine E. M. Allsopp,Frances M. Gotch,Xiao-Ming Gao,Masafumi Takiguchi,Brian Greenwood,Alain Townsend +9 more
TL;DR: Findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.
Journal ArticleDOI
Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
Gavin J. Wright,M J Puklavec,Antony C. Willis,Robert M. Hoek,Jonathon D. Sedgwick,Marion H. Brown,A N Barclay +6 more
TL;DR: The characterization of an OX2 receptor (OX2R) that is a novel protein restricted to cells of the myeloid lineage that could be phosphorylated on tyrosine residues is reported.
Journal ArticleDOI
The Glycosylation and Structure of Human Serum IgA1, Fab, and Fc Regions and the Role of N-Glycosylation on Fcα Receptor Interactions
Taj S. Mattu,Richard J. Pleass,Antony C. Willis,Mogens Kilian,Mark R. Wormald,Annemarie C. Lellouch,Annemarie C. Lellouch,Pauline M. Rudd,Jenny M. Woof,Raymond A. Dwek +9 more
TL;DR: The accessibility of the Cα2N-glycans provides an explanation for the increased sialylation and galactosylation of IgA1 Fc over that of IgG FcN- glycans, which are confined in the space between the two Cγ2 domains.
Journal ArticleDOI
Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle
Garth J. S. Cooper,Brendan Leighton,George Dimitriadis,M. Parry-Billings,J. M. Kowalchuk,Kevin Howland,Jonathan B. Rothbard,Antony C. Willis,Kenneth B.M. Reid +8 more
TL;DR: Amylin may be a factor in the etiology of the insulin resistance in type 2 diabetes mellitus, as both deposition of the peptide in islet amyloid and decreased rates of glucose uptake and glycogen synthesis in skeletal muscle are characteristic of this condition.