C
Catherine M. Cahill
Researcher at University of California, Los Angeles
Publications - 169
Citations - 10277
Catherine M. Cahill is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Opioid & Nociception. The author has an hindex of 53, co-authored 163 publications receiving 8981 citations. Previous affiliations of Catherine M. Cahill include Westmead Hospital & Black Dog Institute.
Papers
More filters
Journal ArticleDOI
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
Jack T. Rogers,Jeffrey Randall,Catherine M. Cahill,Paul S. Eder,Xudong Huang,Hiromi Gunshin,Lorene M. Leiter,Jay McPhee,Satinder Sarang,Tada Utsuki,Nigel H. Greig,Debomoy K. Lahiri,Rudolph E. Tanzi,Ashley I. Bush,Tony Giordano,S. R. Gullans +15 more
TL;DR: Iron regulation of APP mRNA through the APP 5′-UTR points to a role for iron in the metabolism of APP and confirms that this RNA structure can be a target for the selection of small molecule drugs, such as desferrioxamine and clioquinol, which reduce Aβ peptide burden during Alzheimer's disease.
Journal ArticleDOI
TNF-α and neuropathic pain - a review
TL;DR: The intricate link of TNF-α with other neuro-inflammatory signaling systems (e.g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain.
Journal ArticleDOI
Neuropathic pain: a practical guide for the clinician
TL;DR: A primary care algorithm for treatments with the most favourable risk–benefit profile is proposed, including topical lidocaine, gabapentin, pregabalin, tricyclic antidepressants, mixed serotonin–norepinephrine reuptake inhibitors, tramadol and opioids.
Journal ArticleDOI
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
Francesco Ferrini,Francesco Ferrini,Tuan Trang,Theresa-Alexandra M Mattioli,Sophie Laffray,Thomas Del’Guidice,Louis-Etienne Lorenzo,Annie Castonguay,Nicolas Doyon,Wen-Bo Zhang,Antoine G. Godin,Daniela Mohr,Simon Beggs,Karen Vandal,Jean-Martin Beaulieu,Catherine M. Cahill,Catherine M. Cahill,Michael W. Salter,Yves De Koninck +18 more
TL;DR: The findings dissociate morphine-induced hyperalgesia from tolerance and suggest the microglia-to-neuron P2X4-BDNF-KCC2 pathway as a therapeutic target for preventing hyperalGESia without affecting morphine analgesia.
Journal ArticleDOI
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.
Jack T. Rogers,Lorene M. Leiter,Jay McPhee,Catherine M. Cahill,Shan-Shan Zhan,Huntington Potter,Lars N.G. Nilsson +6 more
TL;DR: Enhanced translation of APP mRNA provides a mechanism by which IL-1 influences the pathogenesis of AD, and is homologous to related translational control elements in the 5′-UTR of the light and and heavy ferritin genes.