Cathy Malcontenti-Wilson

TL;DR: SMA-pirarubicin damages tumor cells and the tumor microvasculature and enhances tumor vessel permeability, but tumor necrosis is incomplete, and the growth of residual cells is sustained by a microvascular network.

TL;DR: Diffuser-tipped optical fiber appears to significantly increase the diameter of ILH-induced tumor necrosis compared to the bare fiber, in contrast to thebare fiber, which enables the application of laser energy using higher power settings without compromising theiameter of tumor Necrosis achieved.

TL;DR: CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule polymerization and has considerable potential as a novel anticancer agent.

TL;DR: Findings reveal the MoCR mouse model exhibits significant cachexia and is a suitable preclinical model of cachexia in colorectal liver metastases, which should be used for identifying effective treatments for cachexia to improve quality of life and reduce mortality in patients with coloreCTal liver cancer metastases.

TL;DR: The findings suggest that O Xi4503 selectively targets tumor vessels and causes immediate microvascular destruction, and a combination of OXi4503 with other chemotherapeutic modalities might achieve complete tumor eradication and improve long-term survival.