S
Soo San Wan
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 7
Citations - 610
Soo San Wan is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Ligand (biochemistry) & Actin. The author has an hindex of 7, co-authored 7 publications receiving 536 citations. Previous affiliations of Soo San Wan include University of Melbourne.
Papers
More filters
Journal ArticleDOI
The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Jian-Guo Zhang,Jian-Guo Zhang,Peter E. Czabotar,Peter E. Czabotar,Antonia N. Policheni,Antonia N. Policheni,Irina Caminschi,Irina Caminschi,Irina Caminschi,Soo San Wan,Susie Kitsoulis,Susie Kitsoulis,Kirsteen M. Tullett,Kirsteen M. Tullett,Adeline Y. Robin,Adeline Y. Robin,Rajini Brammananth,Mark F. van Delft,Mark F. van Delft,Jinhua Lu,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Emma C. Josefsson,Emma C. Josefsson,Benjamin T. Kile,Benjamin T. Kile,Wei Jin Chin,Wei Jin Chin,Justine D. Mintern,Justine D. Mintern,Maya A. Olshina,Maya A. Olshina,Wilson Wong,Jake Baum,Jake Baum,Mark D. Wright,David C.S. Huang,David C.S. Huang,Narla Mohandas,Ross L. Coppel,Peter M. Colman,Peter M. Colman,Nicos A. Nicola,Nicos A. Nicola,Ken Shortman,Ken Shortman,Mireille H. Lahoud,Mireille H. Lahoud,Mireille H. Lahoud +48 more
TL;DR: It is proposed that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.
Journal ArticleDOI
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H. Lahoud,Fatma Ahmet,Susie Kitsoulis,Soo San Wan,David Vremec,Chin-Nien Lee,Belinda Phipson,Wei Shi,Wei Shi,Gordon K. Smyth,Andrew M. Lew,Yu Kato,Scott N. Mueller,Gayle M. Davey,William R. Heath,Ken Shortman,Ken Shortman,Irina Caminschi,Irina Caminschi +18 more
TL;DR: Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells.
Journal ArticleDOI
CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo
Christopher J. Burns,Emmanuelle Fantino,Ian D Phillips,Stephen Su,Michael Francis Harte,P. Bukczynska,Mark Frazzetto,Max Joffe,Irma Kruszelnicki,Bing Wang,Yue Wang,Neil Wilson,Rodney J. Dilley,Soo San Wan,Susan A. Charman,David M. Shackleford,Rosa Fida,Cathy Malcontenti-Wilson,Andrew F. Wilks +18 more
TL;DR: CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule polymerization and has considerable potential as a novel anticancer agent.
Journal ArticleDOI
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Mark F. van Delft,Mark F. van Delft,Stephane Chappaz,Stephane Chappaz,Stephane Chappaz,Yelena Khakham,Yelena Khakham,Chinh T. Bui,Chinh T. Bui,Marlyse A. Debrincat,Marlyse A. Debrincat,Kym N Lowes,Kym N Lowes,Jason M. Brouwer,Jason M. Brouwer,Christoph Grohmann,Christoph Grohmann,Phillip P. Sharp,Phillip P. Sharp,Laura F. Dagley,Laura F. Dagley,Lucy Li,Lucy Li,Kate McArthur,Kate McArthur,Kate McArthur,Meng Xiao Luo,Meng Xiao Luo,Hui San Chin,Hui San Chin,W. Douglas Fairlie,Erinna F. Lee,David J. Segal,David J. Segal,Stephane Duflocq,Stephane Duflocq,Romina Lessene,Romina Lessene,Sabrina Bernard,Sabrina Bernard,Laure Peilleron,Laure Peilleron,Thao Nguyen,Thao Nguyen,Caroline Miles,Caroline Miles,Soo San Wan,Soo San Wan,Rachael M. Lane,Rachael M. Lane,Rachael M. Lane,Ahmad Wardak,Ahmad Wardak,Kurt Lackovic,Kurt Lackovic,Peter M. Colman,Peter M. Colman,Jarrod J. Sandow,Jarrod J. Sandow,Andrew I. Webb,Andrew I. Webb,Peter E. Czabotar,Peter E. Czabotar,Grant Dewson,Grant Dewson,Keith G. Watson,Keith G. Watson,David C.S. Huang,David C.S. Huang,Guillaume Lessene,Guillaume Lessene,Benjamin T. Kile,Benjamin T. Kile,Benjamin T. Kile +73 more
TL;DR: It is shown that WEHI-9625, a novel tricyclic sulfone small molecule, binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK, demonstrating that blocking apoptosis at an early stage is both advantageous and pharmacologically tractable.
Journal ArticleDOI
Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.
Louisa J. Phillipson,David J. Segal,Tracy L. Nero,Michael W. Parker,Soo San Wan,Melanie de Silva,Mark A. Guthridge,Andrew H. Wei,Christopher J. Burns,Christopher J. Burns +9 more
TL;DR: This series of studies towards the discovery of selective CDK9 inhibitors is based on a pyrazolo[1,5-a]pyrimidine nucleus and the resultant lead compound 18b is devoid of the structural liabilities present in PIK-75 and possesses greater selectivity.