Showing papers by "Cedric S. Raine published in 1971"
104 citations
TL;DR: Studies using electron microscopy and immunofluorescence have been performed on cells infected with five different groups of temperature-sensitive mutants of reovirus type 3, and it is suggested that the latter three genetic groups consist of mutants with defects in virion assembly.
90 citations
TL;DR: The morphogenesis of the Edmonston strain of measles is described in cultures of hamster dorsal-root ganglion maintained for as long as 63 days postinoculation, and intranuclear inclusions mimic those seen in subacute sclerosing panencephalitis.
Abstract: The morphogenesis of the Edmonston strain of measles is described in cultures of hamster dorsal-root ganglion maintained for as long as 63 days postinoculation. The patterns observed confirmed those previously reported in both neural and non-neural tissue. However, in the present tissue, the development of viral material could be followed chronologically within different cell types such as neurons and Schwann cells. Active replication was visualized up to 63 days postinoculation. The appearance of cytoplasmic nucleocapsid preceded that of intranuclear nucleocapsid, the latter occurring after 14 days. These intranuclear inclusions were formed after the transformation of the nucleoli into bizarre pleomorphic bodies which eventually segregated into clumps of nucleocapsid. These intranuclear inclusions mimic those seen in subacute sclerosing panencephalitis, now known to be etiologically related to a measles-like virus.
47 citations