Showing papers by "César A.N. Catalán published in 2017"
TL;DR: Minteguiaga et al. as discussed by the authors presented the work of the Instituto de Quimica del Noroeste (IQN) in the field of Bioquimica and Bio-Bio-Quimica.
28 citations
TL;DR: In an in vivo model of Trypanosoma cruzi infection, deoxymikanolide was able to decrease the parasitemia and the weight loss associated to the acute phase of the parasite infection, and while 100% of control mice died by day 22 after receiving a lethal T. cruziinfected mice survived, 70% of de oxymkanolide-treated mice survived.
Abstract: Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4% for Mikania variifolia and 21.0% and 6.4% for Mikania micrantha respectively, calculated on extract dry weight). Mikanolide, deoxymikanolide and dihydromikanolide were active against Trypanosoma cruzi epimastigotes (50% inhibitory concentrations of 0.7, 0.08 and 2.5 μg/mL, for each compound respectively). These sesquiterpene lactones were also active against the bloodstream trypomastigotes (50% inhibitory concentrations for each compound were 2.1, 1.5 and 0.3 μg/mL, respectively) and against amastigotes (50% inhibitory concentrations for each compound were 4.5, 6.3 and 8.5 μg/mL, respectively). By contrast, scandenolide was not active on Trypanosoma cruzi. Besides, mikanolide and deoxymikanolide were also active on Leishmania braziliensis promastigotes (50% inhibitory concentrations of 5.1 and 11.5 μg/mL, respectively). The four sesquiterpene lactones were tested for their cytotoxicity on THP 1 cells. Deoxymikanolide presented the highest selectivity index for trypomastigotes (SI = 54) and amastigotes (SI = 12.5). In an in vivo model of Trypanosoma cruzi infection, deoxymikanolide was able to decrease the parasitemia and the weight loss associated to the acute phase of the parasite infection. More importantly, while 100% of control mice died by day 22 after receiving a lethal T. cruzi infection, 70% of deoxymikanolide-treated mice survived. We also observed that this compound increased TNF-α and IL-12 production by macrophages, which could contribute to control T. cruzi infection.
27 citations
TL;DR: In this paper, the structural, electronic, topological and vibrational properties of N -3,4-dimethoxybenzyl-hexadecanamide (DMH) were characterized by using Fourier Transform Infrared (FT-IR) and Raman spectroscopies.
25 citations
TL;DR: The composition of essential oils from leaves of Kazakhstan medicinal plants was analysed by GC-MS and associated the antifungal activity with the presence of borneol, camphor, camphene, 1,8-cineole,α- and β-thujone, and of the oxygenated monoterpenes.
21 citations
TL;DR: Qualitative and quantitative differences were observed in the composition of the essential oil from both species and Anatomically stands out the presence of secretory cavities and glandular trichomes in foliar blades and secretory ducts in stems and petiole of both species.
Abstract: The essential oil composition and morpho-anatomy of Tagetes minuta, collected at “El Mollar” and two different populations of Tagetes terniflora collected in Tafi del Valle (Tucuman, Argentina) were studied. The essential oil of aerial parts (flowers and leaves) from both species was analyzed by gas chromatography-mass spectrometry. Qualitative and quantitative differences were observed inthe composition of the essential oil from both species. Oxygenated monoterpenes were the dominant compounds in the essential oil from both collections of T. terniflora where the main component was cis-tagetone (33.6% and 58.4% respectively) accompanied by significant amounts of the monotepene hydrocarbon cis-?-ocimene (17.1% and 17.4% respectively). cis-Tagetone (53.2%) was also a dominant component in T. minuta along with dihydrotagetone (10.4%) and cis-?-ocimene (19.9%). cis- and transocimenonewere distinctive components of T. terniflora which were not detected in T. minuta. Anatomically stands out the presence of secretory cavities and glandular trichomes in foliar blades and secretory ducts in stems and petiole of both species.
8 citations
TL;DR: In this paper, a detailed analysis of the solid state molecular interactions of compounds 3 and 4 has been performed using Hirshfeld surface analysis and their associated 2D fingerprint plots, and the optimized structures were further subjected to a Natural Bond Orbital (NBO) and electrostatic potentials analysis.
5 citations
TL;DR: These findings suggest that PALK constituents might restrict the adherence of F. graminearum to the surface of its hosts and its virulence on susceptible cereals and deserve further research as additives of azole fungicides against F. Graminearums.
3 citations
TL;DR: The use of the diazonium salts Fast Blue B ½ZnCl2 and Fast Blue RR ZnCl 2 for the in situ histochemical localization of urushiols in stems and leaflets of S. lorentzii and S. marginata is proposed.
1 citations