Showing papers by "César A.N. Catalán published in 2020"
TL;DR: The results indicate that eupatoriopicrin could be considered a promising candidate for the development of new therapeutic agents for Chagas disease.
Abstract: The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been found to be active against Trypanosoma cruzi epimastigotes. The aim of this work was to evaluate the activity of these compounds by analyzing their effect against the stages of the parasites that are infective for the human. Even more interesting, we aimed to determine the effect of the most active and selective compound on an in vivo model of T. cruzi infection. Eupatoriopicrin was the most active against amastigotes and tripomastigotes (IC50 = 2.3 µg/mL, and 7.2 µg/mL, respectively) and displayed a high selectivity index. This compound was selected to study on an in vivo model of T. cruzi infection. The administration of 1 mg/kg/day of eupatoriopicrin for five consecutive days to infected mice produced a significant reduction in the parasitaemia levels in comparison with non-treated animals (area under parasitaemia curves 4.48 vs. 30.47, respectively). Skeletal muscular tissues from eupatopicrin-treated mice displayed only focal and interstitial lymphocyte inflammatory infiltrates and small areas of necrotic; by contrast, skeletal tissues from T. cruzi infected mice treated with the vehicle showed severe lymphocyte inflammatory infiltrates with necrosis of the adjacent myocytes. The results indicate that eupatoriopicrin could be considered a promising candidate for the development of new therapeutic agents for Chagas disease.
17 citations
TL;DR: The trans-nerolidol chemotype, which grows naturally in the province of La Rioja (Puerto Alegre), presents the best qualities for the medicinal use of the species, due to its higher yield in aqueous extracts and higher phenolic and flavonoid content.
5 citations
TL;DR: In this paper, the 3-(2,3-dihydroxy-isopentyl)-4-hydroxyacetophenone was synthesized and characterized by 1H Nuclear Magnetic Resonance (NMR), Infrared (IR) and Raman spectroscopies and its crystal structure was solved by single crystal X-ray diffraction.
3 citations
TL;DR: The results indicate that the leaf methanol extract of P. nigra deserves further research as an additive of azole fungicides applied for the control of C. kikuchii and S. glycines.
1 citations
01 Nov 2020
TL;DR: In this article, Ledesma et al. present the Centro de Investigacion en Biofisica Aplicada and Alimentos (CIBALA) as a tool for the analysis of bio-medical data.
Abstract: Fil: Ledesma, Ana Estela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Centro de Investigacion en Biofisica Aplicada y Alimentos. - Universidad Nacional de Santiago del Estero. Centro de Investigacion en Biofisica Aplicada y Alimentos; Argentina