C
Chad E. Darling
Researcher at University of Massachusetts Medical School
Publications - 67
Citations - 2030
Chad E. Darling is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Population & Acute decompensated heart failure. The author has an hindex of 23, co-authored 66 publications receiving 1721 citations. Previous affiliations of Chad E. Darling include UMass Memorial Health Care & University of Massachusetts Amherst.
Papers
More filters
Journal ArticleDOI
Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
Chad E. Darling,Rong Jiang,Michelle Maynard,Peter Whittaker,Jakob Vinten-Johansen,Karin Przyklenk +5 more
TL;DR: The results implicate the involvement of ERK1/2 rather than PI3-kinase/Akt in the reduction of infarct size achieved with post-C, which was supported by pharmacological data, which showed increased immunoreactivity of phospho-ERK but notospho-Akt withPost-C.
Journal ArticleDOI
PULSE-SMART: Pulse-Based Arrhythmia Discrimination Using a Novel Smartphone Application
David D. McManus,David D. McManus,Jo Woon Chong,Apurv Soni,Jane S. Saczynski,Nada Esa,Craig Napolitano,Chad E. Darling,Edward W. Boyer,Rochelle K. Rosen,Kevin C. Floyd,Ki H. Chon +11 more
TL;DR: Smartphones are increasingly used for mobile health applications by older patients at risk for AF and may be useful for AF screening.
Journal ArticleDOI
Aging Mouse Hearts Are Refractory to Infarct Size Reduction With Post-Conditioning
TL;DR: This article showed that post-conditioning significantly reduced infarct size via up-regulation of ERK (but not Akt) signaling in older mice, possibly due to an age-associated increase in MKP-1 and resultant deficit in ERK phosphorylation.
Journal ArticleDOI
Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injury
TL;DR: A retrospective chart review of 215 cases of rhabdomyolysis with CPK of ≥1,000 U/L found AST concentrations decrease in parallel to CPK, suggesting skeletal muscle may be a significant source of AST elevation in these patients.
Journal ArticleDOI
Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning.
TL;DR: This review describes the initial observations that provided the impetus for the study of ‘remote preconditioning’, and summarizes the current knowledge of the three facets of ’preconditioning at a distance’ – intra-cardiac, inter-organ and transferred inter-Cardiac preconditionsing.