P
Peter Whittaker
Researcher at Wayne State University
Publications - 130
Citations - 8397
Peter Whittaker is an academic researcher from Wayne State University. The author has contributed to research in topics: Ischemic preconditioning & Ischemia. The author has an hindex of 41, co-authored 130 publications receiving 8073 citations. Previous affiliations of Peter Whittaker include University of Massachusetts Amherst & London School of Economics and Political Science.
Papers
More filters
Journal ArticleDOI
Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.
TL;DR: Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model, and implies that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemic/reperfusion.
Journal ArticleDOI
Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.
TL;DR: The issue of whether oxygen free radical scavengers are capable of reducing so-called irreversible or lethal reperfusion injury remains, in this opinion, unresolved and should not be considered a deterrent to reperfusions for the treatment of acute myocardial infarcts in the clinical setting.
Journal ArticleDOI
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.
Jochen Müller-Ehmsen,Peter Whittaker,Robert A. Kloner,Joan Dow,Tsuyoshi Sakoda,Tiffany I. Long,Peter W. Laird,Larry Kedes +7 more
TL;DR: A quantitative survival profile for neonatal cardiomyocytes transplanted into normal adult myocardium is established, revealing that transplanted cells became more elongated over time, developed cross-striations, and that their nuclei increased in size.
Journal ArticleDOI
Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light.
TL;DR: Analysis using circularly polarized light has the ability to enhance histologic assessment of tissue and can provide additional insights into the composition and structure of myocardial collagen.
Journal ArticleDOI
Human Semilunar Cardiac Valve Remodeling by Activated Cells From Fetus to Adult Implications for Postnatal Adaptation, Pathology, and Tissue Engineering
Elena Aikawa,Peter Whittaker,Mark Farber,Karen Mendelson,Robert F. Padera,Masanori Aikawa,Frederick J. Schoen +6 more
TL;DR: Fetal valves possess a dynamic/adaptive structure and contain cells with an activated/immature phenotype, which suggests a progressive, environmentally mediated adaptation.