Chandra Dodia

TL;DR: The results suggest that Ser32 in the GDSWG consensus sequence provides the catalytic nucleophile for the hydrolase activity of aiPLA2, while Cys47 in the PVCTTE consensus sequence is at the active site for peroxidase activity.

TL;DR: This study investigated phospholipid hydroperoxides as substrates for non-selenium GSH peroxidase (NSGPx), an enzyme also called 1-Cys peroxiredoxin, which is an important component of cellular antioxidant defense systems.

TL;DR: It is demonstrated that ROS production in lungs exposed to ischemia or high K+ results from assembly and activation of a membrane-associated NAPDH oxidase of the pulmonary endothelium, and the increased dichlorofluorescein fluorescence in these models of ROS generation was localized primarily to the pulmonary artery endothelial cells.

TL;DR: It is concluded that flow-adapted endothelial cells generate ROS with ischemia that results in activation of NF-kappaB and AP-1 and an increase of DNA synthesis and this effect is not mediated by hypoxia, implicating a role for mechanotransduction in ischemIA-mediated cell signaling.

TL;DR: It is suggested that ABCA3 is necessary for lamellar body biogenesis, surfactant protein-B processing, and lung development late in gestation, since the fraction of near term Abca3/– embryos was significantly lower than expected from Mendelian inheritance.