Chandy C. John

TL;DR: Possible mechanisms of brain injury in cerebral malaria are examined, relating this to the pathogenesis of the disease, and prospects for improved neurocognitive outcome are explored.

TL;DR: Cerebral malaria is associated with long-term cognitive impairments in 1 of 4 child survivors and future studies should investigate the mechanisms involved so as to develop interventions aimed at prevention and rehabilitation.

TL;DR: Cerebral malaria may be a major cause of cognitive impairment in children in sub-Saharan Africa and cognitive deficits in children with cerebral malaria are more likely for those who have multiple seizures before effective treatment for cerebral malaria.

TL;DR: A case in which third-generation cephalosporin failed in the treatment of pneumococcal meningitis is documents and the clinical and microbiological features of the seven similar cases reported to date are reviewed, suggesting that children with intermediately penicillin-resistant pneumococ calmeningitis are best treated with vancomycin and rifampin until the MICs of cefotaxime and ceftriaxone for the pneumococcus are known.

TL;DR: Angiopoietin-1 and the ANG-2/1 ratio are promising clinically informative biomarkers for CM and additional studies should address their utility as prognostic biomarkers and potential therapeutic targets in severe malaria.