R
Robert O. Opoka
Researcher at Makerere University
Publications - 206
Citations - 6345
Robert O. Opoka is an academic researcher from Makerere University. The author has contributed to research in topics: Malaria & Medicine. The author has an hindex of 33, co-authored 170 publications receiving 4927 citations. Previous affiliations of Robert O. Opoka include Mulago Hospital & College of Health Sciences, Bahrain.
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Journal ArticleDOI
Mortality after Fluid Bolus in African Children with Severe Infection
Kathryn Maitland,Sarah Kiguli,Robert O. Opoka,Charles Engoru,Peter Olupot-Olupot,Samuel Akech,Richard Nyeko,George Mtove,Hugh Reyburn,Trudie Lang,Bernadette Brent,Jennifer Evans,James K. Tibenderana,Jane Crawley,Elizabeth C. Russell,Michael Levin,Abdel Babiker,Diana M. Gibb +17 more
TL;DR: Fuid boluses significantly increased 48-hour mortality in critically ill children with impaired perfusion in these resource-limited settings in Africa.
Journal ArticleDOI
Cerebral malaria in children is associated with long-term cognitive impairment
Chandy C. John,Paul Bangirana,Justus Byarugaba,Robert O. Opoka,Richard Idro,Anne M. Jurek,Baolin Wu,Michael J. Boivin +7 more
TL;DR: Cerebral malaria is associated with long-term cognitive impairments in 1 of 4 child survivors and future studies should investigate the mechanisms involved so as to develop interventions aimed at prevention and rehabilitation.
Journal ArticleDOI
Cognitive Impairment After Cerebral Malaria in Children: A Prospective Study
Michael J. Boivin,Paul Bangirana,Justus Byarugaba,Robert O. Opoka,Richard Idro,Anne M. Jurek,Chandy C. John +6 more
TL;DR: Cerebral malaria may be a major cause of cognitive impairment in children in sub-Saharan Africa and cognitive deficits in children with cerebral malaria are more likely for those who have multiple seizures before effective treatment for cerebral malaria.
Journal ArticleDOI
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
Kathryn Maitland,Elizabeth C George,Jennifer Evans,Sarah Kiguli,Peter Olupot-Olupot,Samuel Akech,Robert O. Opoka,Charles Engoru,Richard Nyeko,George Mtove,Hugh Reyburn,Bernadette Brent,Julius Nteziyaremye,Ayub Mpoya,Natalie Prevatt,Cornelius M Dambisya,Daniel Semakula,Ahmed Ddungu,Vicent Okuuny,Ronald Wokulira,Molline Timbwa,Benedict Otii,Michael Levin,Jane Crawley,Abdel Babiker,Diana M. Gibb +25 more
TL;DR: Excess mortality from boluses occurred in all subgroups of children and should prompt a re-evaluation of evidence on fluid resuscitation for shock and are-appraisal of the rate, composition and volume of resuscitation fluids.
Journal ArticleDOI
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children.
Fiona E. Lovegrove,Noppadon Tangpukdee,Robert O. Opoka,Erin I. Lafferty,Nimerta Rajwans,Michael Hawkes,Srivicha Krudsood,Sornchai Looareesuwan,Chandy C. John,W. Conrad Liles,W. Conrad Liles,Kevin C. Kain,Kevin C. Kain +12 more
TL;DR: Angiopoietin-1 and the ANG-2/1 ratio are promising clinically informative biomarkers for CM and additional studies should address their utility as prognostic biomarkers and potential therapeutic targets in severe malaria.