M
Michael Hawkes
Researcher at University of Alberta
Publications - 153
Citations - 3599
Michael Hawkes is an academic researcher from University of Alberta. The author has contributed to research in topics: Malaria & Medicine. The author has an hindex of 31, co-authored 134 publications receiving 2837 citations. Previous affiliations of Michael Hawkes include Makerere University & University of Toronto.
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Journal ArticleDOI
Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.
Daniel R. Ricciuto,Claudia C. dos Santos,Michael Hawkes,Lisa J. Toltl,Andrea L. Conroy,Nimerta Rajwans,Erin I. Lafferty,Deborah J. Cook,Alison Fox-Robichaud,Kamyar Kahnamoui,Kevin C. Kain,Patricia C. Liaw,W. Conrad Liles +12 more
TL;DR: The use of angiopoietins as clinically informative biomarkers of disease severity and patient outcome in severe sepsis is suggested.
Journal ArticleDOI
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children.
Fiona E. Lovegrove,Noppadon Tangpukdee,Robert O. Opoka,Erin I. Lafferty,Nimerta Rajwans,Michael Hawkes,Srivicha Krudsood,Sornchai Looareesuwan,Chandy C. John,W. Conrad Liles,W. Conrad Liles,Kevin C. Kain,Kevin C. Kain +12 more
TL;DR: Angiopoietin-1 and the ANG-2/1 ratio are promising clinically informative biomarkers for CM and additional studies should address their utility as prognostic biomarkers and potential therapeutic targets in severe malaria.
Journal ArticleDOI
Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study
Laura K. Erdman,Aggrey Dhabangi,Charles Musoke,Andrea L. Conroy,Michael Hawkes,Sarah J. Higgins,Nimerta Rajwans,Kayla T. Wolofsky,David L. Streiner,W. Conrad Liles,W. Conrad Liles,Christine Cserti-Gazdewich,Kevin C. Kain,Kevin C. Kain +13 more
TL;DR: Results suggest the utility of combinatorial biomarker strategies as prognostic tests for severe malaria and generated simple biomarker combinations that accurately predicted death in an African pediatric population.
Journal ArticleDOI
Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study
Andrea L. Conroy,Happy T. Phiri,Michael Hawkes,Simon J. Glover,Mac Mallewa,Mac Mallewa,Karl B. Seydel,Karl B. Seydel,Terrie E. Taylor,Terrie E. Taylor,Malcolm E. Molyneux,Malcolm E. Molyneux,Malcolm E. Molyneux,Kevin C. Kain,Kevin C. Kain +14 more
TL;DR: Results suggest that endothelial proteins are informative biomarkers of malarial disease severity and require validation in prospective studies to confirm that this group of biomarkers improves the diagnostic accuracy of CM from similar conditions causing fever and altered consciousness.
Journal ArticleDOI
The Epidemiology, Management, and Outcomes of Bacterial Meningitis in Infants
Lynda Ouchenir,Christian Renaud,Sarah Khan,Ari Bitnun,Andree-Anne Boisvert,Jane McDonald,Jennifer Bowes,Jason Brophy,Michelle Barton,Joseph Ting,Ashley Roberts,Michael Hawkes,Joan L. Robinson +12 more
TL;DR: E coli and GBS remain the most common causes of bacterial meningitis in the first 90 days of life, and one should consider a third-generation cephalosporin (plus ampicillin for at least the first month) for empirical therapy of suspected Meningitis if there is evidence for Gram-negativeMeningitis.