Changli Ge

TL;DR: Generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for known receptor proteins CD163 and pAPN are reported and it is shown that DKO pigs are completely resistant to genotype 2 PRRSV and TGEV.

TL;DR: 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 are identified using scRNA-seq technology coupled with a deep and comprehensive analysis of unique cell surface markers and differentially expressed genes.

TL;DR: OmicStudio as discussed by the authors is a one-stop online analysis platform providing high-throughput omics data analysis, as well as an exploratory platform for bioinformatics research, which focuses on speed, quality together with flexibility.

TL;DR: In this article, a dual gene knockout vector system is proposed, which includes a CD163 gene and a CD13 gene knockout vectors, where the vector system includes a gene editing vector skeleton and a DNA fragment linked to the vector skeleton, and the nucleotide sequence of the DNA fragment is represented by any one of SEQ ID No.

TL;DR: An untargeted mass spectrometry microprotein profiling method is developed and identified a signature of cystatin A, validated this protein in an animal model, and sought to overcome the limits of detection inherent to mass Spectrometry by demonstrating that cystatar A is present at 100 pM concentrations using a label-free microtoroid resonator.