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Changning Guo
Researcher at Food and Drug Administration
Publications - 27
Citations - 503
Changning Guo is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Vibrational circular dichroism & Enantiomeric excess. The author has an hindex of 12, co-authored 27 publications receiving 440 citations. Previous affiliations of Changning Guo include Academia Sinica & Syracuse University.
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Determination of enantiomeric excess in samples of chiral molecules using Fourier transform vibrational circular dichroism spectroscopy: Simulation of real-time reaction monitoring
TL;DR: The first use of Fourier transform vibrational circular dichroism (FT-VCD) to follow changes in the percent enantiomeric excess (% EE) of chiral molecules in time using a flow cell sampling apparatus is reported.
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Fourier transform vibrational circular dichroism from 800 to 10,000 cm−1: Near-IR-VCD spectral standards for terpenes and related molecules
Changning Guo,Rehka D. Shah,Rina K. Dukor,Teresa B. Freedman,Xiaolin Cao,Laurence A. Nafie,Laurence A. Nafie +6 more
TL;DR: In this article, a set of vibrational circular dichroism (VCD) spectra for enantiomeric pairs of molecules with three ChiralIR Fourier transform (FT) VCD spectrometers equipped with various light sources and detectors and modified for dual polarization modulation (DPM) operation were obtained.
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Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design.
TL;DR: The quadratic models developed from the DOE study quantitatively describe the inherent relationships between the factors and nasal spray performance characteristics, so that the time and labor in designing a nasal spray product to achieve desired product performance characteristics can be reduced.
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Extension of fourier transform vibrational circular dichroism into the near-infrared region: continuous spectral coverage from 800 to 10 000 cm(-1).
TL;DR: This study demonstrates that with modern FT-VCD spectrometers modified for DPM operation, VCD spectra can be measured continuously across a wide spectral range from the MIR to nearly the visible region with an unsurpassed combination of signal-to-noise ratio and spectral resolution.
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Evaluation of droplet velocity and size from nasal spray devices using phase Doppler anemometry (PDA).
TL;DR: In this paper, phase Doppler anemometry (PDA) was used to simultaneously characterize the aerosol velocity and droplet size distribution of three nasal spray pumps filled with water.