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Changshun Yu
Researcher at Tianjin Medical University
Publications - 3
Citations - 6
Changshun Yu is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Gene expression & Wild type. The author has an hindex of 2, co-authored 3 publications receiving 6 citations.
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Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury
Bilon Khambu,Tiangang Li,Shengmin Yan,Changshun Yu,Xiaoyun Chen,Michael P. Goheen,Yong Li,Jingmei Lin,Oscar W. Cummings,Young-Min Lee,Scott L. Friedman,Zheng Dong,Gen-Sheng Feng,Shangwei Wu,Xiao Ming Yin +14 more
TL;DR: It is found that autophagy sustained and promoted the basal and upregulated expression of Fxr in the fed and starved conditions, respectively, and expression ofFxr and its downstream genes, particularly Bsep, and the binding of FXR to the promoter regions of these genes, were suppressed in Autophagy-deficient livers.
Journal ArticleDOI
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.
Changshun Yu,Shengmin Yan,Bilon Khambu,Xiaoyun Chen,Zheng Dong,Jianhua Luo,George K. Michalopoulos,Shangwei Wu,Xiao Ming Yin +8 more
TL;DR: In this article, gene expression analysis in wild type and bid-deficient mice treated with a hepatic carcinogen, diethylnitrosamine, showed that deletion of Bid caused significantly fewer alterations in gene expression in terms of the number of genes affected and pathways affected in addition, the expression profiles were remarkably different In the wild type mice, there was a significant increase in the expression of growth regulation-related and immune/inflammation response-related genes, and a significant decrease in metabolism related genes.
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers
Changshun Yu,Shengmin Yan,Bilon Khambu,Xiaoyun Chen,Zheng Dong,Jianhua Luo,George K. Michalopoulos,Shangwei Wu,Xiao Ming Yin +8 more
TL;DR: Gene expression analysis in wild type and bid-deficient mice treated with a hepatic carcinogen and deletion of Bid found that deletion caused significantly fewer alterations in gene expression in terms of the number of genes affected and theNumber of pathways affected.