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Bilon Khambu

Researcher at Indiana University

Publications -  49
Citations -  7664

Bilon Khambu is an academic researcher from Indiana University. The author has contributed to research in topics: Autophagy & Liver injury. The author has an hindex of 20, co-authored 45 publications receiving 5988 citations. Previous affiliations of Bilon Khambu include Indiana University – Purdue University Indianapolis & B.P. Koirala Institute of Health Sciences.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.

Min Li, +9 more
- 13 Dec 2013 - 
TL;DR: Niclosamide was shown to be ineffective in inhibiting MTORC1 in cells expressing constitutively activated Rag proteins, suggesting that its inhibitory effects were targeted to the Rag/RRAG GTPase pathway as discussed by the authors.
Journal ArticleDOI

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Youngmin A. Lee, +28 more
- 23 Nov 2018 - 
TL;DR: It is shown that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and this association in human liver cancer tissues is established, shedding new light on mechanisms of YAP degradation and the sequence of events that follow disruption of autophagy.
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Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

Lisa Asano, +10 more
- 16 Feb 2017 - 
TL;DR: 25-hydroxyvitamin D (25OHD) impairs SREBP activation by inducing proteolytic processing and ubiquitin-mediated degradation of SCAP, thereby decreasing SRE BP levels independently of the vitamin D receptor.