Chao Huang

TL;DR: The substitution-cyclization reaction of heterocyclic ketene aminals with polyhalo isophthalonitrile in the presence of t-BuOK to form 1,3-diazaheterocycle fused [1,2-b]isoquinolin-1(2H)-imines, followed by hydrolysis with 1 N HCl, provides a concise and efficient route for the synthesis of highly functionalpolyhalo 1, 3-diasheterocy

TL;DR: The results indicated that compounds 5c, 6c and 6h inhibit S(180) and H(22) growth and have very low acute toxicities, and the preliminary analysis of structure-activity relationships is discussed.

TL;DR: A combination of experimental and computational approaches facilitates us to understand the molecular mechanism of inhibitory action and discover more potent non-steroidal AIs against aromatase, thereby opening up a novel therapeutic strategy for hormone-dependent breast cancer.

TL;DR: Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions and could react smoothly to give the alkynylated products in moderate to good yields and enantioselectivities.

TL;DR: Employing a series of norbornadiene derivatives as substrates, the effects of various substituents on the Ir-catalyzed asymmetric [2 + 2] cycloaddition reactions with arylacetylenes were studied and it was found that the atom forming the short bridge chain had a great effect on the enantioselectivity of the reaction.