C
Chao Zhai
Researcher at King's College London
Publications - 5
Citations - 111
Chao Zhai is an academic researcher from King's College London. The author has contributed to research in topics: Mutant & Tetratricopeptide. The author has an hindex of 3, co-authored 5 publications receiving 101 citations.
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Journal ArticleDOI
Chaperone ligand-discrimination by the TPR-domain protein Tah1
Stefan H. Millson,Cara K. Vaughan,Chao Zhai,Maruf M.U. Ali,Barry Panaretou,Peter W. Piper,Laurence H. Pearl,Chrisostomos Prodromou +7 more
TL;DR: Tah1 acheives ligand discrimination by favourably binding the methionine residue in the conserved MEEVD motif (Hsp90) and positively discriminating against the first valine residues in the VEEVD logo motif (Ssa1).
Journal ArticleDOI
The heat shock proteins: Their roles as multi-component machines for protein folding
Barry Panaretou,Chao Zhai +1 more
TL;DR: This work has revealed the action of heat shock proteins in fungi as multi-component machines, playing roles in signalling and expansion of phenotypic plasticity, as well as their well-established function as molecular chaperones.
Journal ArticleDOI
Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane.
Chao Zhai,Kuoyu Li,Valentini Markaki,John P. Phelan,Katherine Bowers,Frank T. Cooke,Barry Panaretou +6 more
TL;DR: It is demonstrated that phenotypes of ypp1 and stt4 conditional mutants are identical, namely osmoremedial temperature sensitivity, hypersensitivity to cell wall destabilizers and defective organization of actin, and that overexpression of STT4 suppresses the temperature-sensitive growth defect of Ypp1 mutants.
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Emw1p/YNL313cp is essential for maintenance of the cell wall in Saccharomyces cerevisiae
TL;DR: Emw1(ts) mutants activate this cascade even at permissive temperature, indicating that loss of Emw1p function does not cause a defect in sensors and effectors of cell wall signalling, but leads to a cell wall defect directly.