Chao Zhao

TL;DR: A significant impairment of remyelination is found, attributable to an arrest of the differentiation and not the recruitment of oligodendrocyte precursor cells, which identifies myelin as an inhibitor of remYelination as well as its well documented inhibition of axon regeneration.

TL;DR: It is shown that dysregulation of Wnt-beta-catenin signaling in OLPs results in profound delay of both developmental myelination and remyelination, based on findings from APC(Min) mice, which lack one functional copy of the endogenous Wnt pathway inhibitor APC.

TL;DR: This work has used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions.

TL;DR: The results indicate that the age-associated decrease inRemyelination efficiency occurs because of an impairment of OP recruitment and the subsequent differentiation of the OPs into remyelinating oligodendrocytes, and that strategies aimed at ameliorating the age -associated decline in remyELination efficiency will therefore need to promote both components of the regenerative process.

TL;DR: The results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS.