C
Charles A. Janeway
Researcher at Yale University
Publications - 254
Citations - 57915
Charles A. Janeway is an academic researcher from Yale University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 86, co-authored 254 publications receiving 56217 citations. Previous affiliations of Charles A. Janeway include French Institute of Health and Medical Research & Massachusetts Institute of Technology.
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Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Susan Wong,Sylvie Guerder,Irene Visintin,Eva-Pia Reich,Karl E Swenson,Richard A. Flavell,Charles A. Janeway +6 more
TL;DR: Transgenic mice have been generated that express B7-1 on the β-cells of the pancreatic islets of Langerhans and this illustrates that B 7-1 is a very potent co-stimulatory molecule in vivo and that its presence on the surface of tissue cells can potentiate the autoimmune process.
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Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.
TL;DR: It is demonstrated that the flanking residues of the conalbumin peptide bound to I‐Ak have no effect on recognition by the D10 TCR, and it is found that the peptide flanks residues contribute substantially to MHC binding.
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Further observations on the Swiss type of agammaglobulinemia (alymphocytosis). The effect of syngeneic bone-marrow cells.
TL;DR: A severe, lethal form of agammaglobulinemia associated with alymphocytosis and aplasia of the thymus gland has been described in western Europe and the United States.
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The T cell activation molecule H4 and the CD28-like molecule ICOS are identical.
Donatella Buonfiglio,Manuela Bragardo,Valter Redoglia,Rosanna Vaschetto,Flavia Bottarel,Sara Bonissoni,Thea Bensi,Caterina Mezzatesta,Charles A. Janeway,Umberto Dianzani +9 more
TL;DR: Evaluating whether H4 and ICOS are the same molecule using the C398.4A (binding human and mouse H4) and F44 ( binding human ICOS) monoclonal antibody (mAb) in parallel experiments on human T cells proves it.
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Self-defense: The fruit fly style
TL;DR: The immune system of higher vertebrates consists of innate and adaptive components that differ mainly by the mechanisms of pathogen recognition: the innate immune system uses germ-line encoded receptors to recognize conserved molecular constituents of infectious microorganisms, whereas adaptive immunity is mediated by highly specific antigen receptors.