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Charles A. Janeway
Researcher at Yale University
Publications - 254
Citations - 57915
Charles A. Janeway is an academic researcher from Yale University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 86, co-authored 254 publications receiving 56217 citations. Previous affiliations of Charles A. Janeway include French Institute of Health and Medical Research & Massachusetts Institute of Technology.
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On the intrathymic intercellular transfer of self-determinants
TL;DR: Intercellular transfer of self-determinants within the thymic microenvironment is likely to improve the establishment of central T-cell tolerance and may involve direct displacement of major histocompatibility complex-bound peptides.
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In vitro cultivation of nonlymphoid thymic cells: morphological and immunological characterization.
TL;DR: A striking observation was that thymic epithelial cells could bind and internalize autologous thymocytes and this selective thymocyte ingestion by thymi epithelium may have important implications in regard to processing of T-lymphocyte precursors.
Journal Article
Cellular cooperation during in vivo anti-hapten antibody responses. II. The effect of in vivo and in vitro x-irradiation on T and B cells.
TL;DR: The effect of x-irradiation on T and B cells involved in an in vivo adoptive anti-hapten antibody response has been studied and radioresistant helper effects, observed when normal mice are irradiated 24 hr after being given helper cells, are occasionally observed.
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T-cell development: a role for self-peptides in positive selection.
TL;DR: An important issue for immunologists is the difference between the two main processes that determine the mature repertoire of T-cell receptors, termed positive and negative selection.