C
Charles A. Kettner
Researcher at Wilmington University
Publications - 32
Citations - 813
Charles A. Kettner is an academic researcher from Wilmington University. The author has contributed to research in topics: Thrombin & Discovery and development of direct thrombin inhibitors. The author has an hindex of 16, co-authored 32 publications receiving 803 citations. Previous affiliations of Charles A. Kettner include DuPont.
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Peptide boronic acid inhibitors of trypsin-like proteases
TL;DR: In this paper, C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.
Patent
Alpha-aminoboronic acid peptides
TL;DR: In this article, C-terminal a-aminoboronic acid residues are used as reversible inhibitors of proteolytic enzymes, and they are shown to be a potent, reversible inhibitor of enzymes.
Journal ArticleDOI
Proton magnetic resonance studies of the active center histidine of chymotrypsin complexed to peptideboronic acids: Solvent accessibility to the N.delta. and N.epsilon. sites can differentiate slow-binding and rapidly reversible inhibitors
Journal ArticleDOI
Synthesis of boronic acid analogues of alpha-amino acids by introducing side chains as electrophiles.
TL;DR: The methodology described here allows the preparation of alpha-aminoboronic acids by introducing side chains as electrophiles, particularly advantageous for side chains which are prone to elimination or unwanted enolate formation.
Journal ArticleDOI
Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile
John M. Fevig,Joseph Buriak,Joseph Cacciola,Richard S. Alexander,Charles A. Kettner,Robert M. Knabb,James Russell Pruitt,Patricia C. Weber,Ruth R. Wexler +8 more
TL;DR: Using X-ray crystal structure information, compounds are designed that have greater selectivity for thrombin over factor I and that have reduced tendency to produce side effects.